It Really Isn’t That Simple

Large simple trials: really, it can't be that simple!

In this issue of the European Heart Journal, Calvo et al. present another plea for simplified approaches to clinical trials evaluating cardiovascular therapies. In the interest of disclosure, I note that I work closely with many of the authors of this article. Dr Christopher Granger, in particular, is a long-time collaborator and senior investigator in my own institution. The thesis advanced by...

PREDICTION/ESTIMATION WITH SIMPLE LINEAR MODELS: IS IT REALLY THAT SIMPLE? By

Consider the simple normal linear regression model for estimation/prediction at a new design point. When the slope parameter is not obviously nonzero, hypothesis testing and model selection methods can be used for identifying the right model. We compare performance of such methods both theoretically and empirically from different perspectives for more insight. The testing approach, in spite of ...

Statistical significance: is it really that significant?

Is it Really that Simple? The Complexity of Object Descriptions in Human-Computer Interaction

In the literature on verbal human-computer interaction there is general consent that humans’ preconceptualisations of the machine’s capabilities lead to conceptual and syntactic simplifications of the language used. We present a Wizard of Oz / Confederate study where humans communicate with either a system or an expert in a localization task in a complex building, in a setting which encourages ...

Peroxisome targeting signal 1: is it really a simple tripeptide?

Originally, the peroxisomal targeting signal 1 (PTS1) was defined as a tripeptide at the C-terminus of proteins prone to be imported into the peroxisomal matrix. The corresponding receptor PEX5 initiates the translocation of proteins by identifying potential substrates via their C-termini and trapping PTS1s through remodeling of its TPR domain. Thorough studies on the interaction between PEX5 a...